Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively. Prozac Weekly, the long-acting form approved for depression, can be used to replace daily doses of 20 mg. Because the medication stays in your system for so long, the first dose of Prozac Weekly should be taken one week after stopping Prozac 20 mg daily. Tag Cloud. is pepcid a serotonin antagonist ul maxell lithium caffeine and lower back pain Do you know anything about if you have taken the drug for one month and three weeks. it just started to set in and now you are off of it. If it would take another 4 to 6 weeks to get out of your system? I’ve tried several times to get off Cymbalta, with dr instructions and I became a person I didn’t like. I didn’t know the side effects would be that bad. Upset. Prednisone does cause depression, as well stays in your system for a long time, but since you were on it a short time it could maybe stay in your body for about 2 to 3 weeks. Umpy it's the original anxiety. The reason it feels so crazy is because when you take your medication the way you're supposed to, everything is tamped down. The original 7-step natural treatment program for permanently curing and preventing depression - Without drugs or harmful side-effects. In 2008, Cymbalta became the second drug to receive FDA approval for the treatment of fibromyalgia. It was classified as a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant.