Before using codeine and traMADol together. Using these medications together can increase your risk of seizures, breathing problems, and other side effects. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. Tell your doctor if you have weak or shallow breathing, tremors, restlessness, seizures, or problems. I take codeine and tramadol together, and I know a few others that do to. But it's probably best to ask your doc. xx But it's probably best to ask your doc. xx Reply Codeine is a prescription opiate medication used for mild to moderate pain relief and to reduce coughing. Knowing how long it remains in your system can ensure that you get the needed effects and reduce the risk of an overdose by using the dosage and timing recommended by your doctor. Zocdoc › Answers › How long after taking Tramadol can I take Hydrocodone? Question. I have tramadol for knee pain and hydrcodone for a dental surgey. Its been about 7 hours since the last tramadol dose I want to be safe as the the pain is getting unbearable. Answer. I think the safest thing for you to do is to schedule an appointment with your primary care physician so you can discuss a. Possible effects of Tramadol and Codeine combination can be constipation, tiredness and somnolence. If you maintain the dosage that was prescribed and use them together as doctor said, you wont have any problems. But if you notice anything unusual, contact your doctor. Thanks to all of you guys for good input! Now heres what I did and what happened: 2hrs after 100mg of codeine I dropped 100mg tramadol. After about 50min I could feel a slow and fairly weak tramadol high coming on. I take codeine regularly, no surprise you liked the codeine much more than the tramadol, codeine is AWESOME by itself in my opinion. As for the tramadol, I have never mixed both drugs but I'd love to try, although after reading this post if I ever do I will still to a low mg tramadol & higher mg codeine. I take 400mg a day, two modified release tablets as they are long term meds. You can even mix co-codamol and tramadol, though I wouldn't recommend without a doctor's say so, though I have done during kidney infections. rheumatoid arthritis, anxiety, pain, restless legs syndrome, back pain, fibromyalgia, codeine, tramadol Details: I am such a sissy with pain meds but I've got spinal arthritis and fibro along with restless leg syndrome. Codeine and tramadol are habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief. If tramadol or codeine is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop.