How to use Isotretinoin Capsule. Read the Medication Guide provided by your pharmacist before you start using isotretinoin and each time you get a refill. Accutane is a brand-name prescription medication that contains isotretinoin and is FDA-approved to treat severe nodular acne characterized by numerous cysts on the skin. Does taking Accutane with food OR Accutane with high-fat meal increase absorption? Dear Doctor, Roche said: oral absorption of isotretinoin is enhanced when given with a high-fat meal. Therefore, isotretinoin capsules should always be taken with food (see DOSAGE AND ADMINISTRATION). Clinical studies have shown that there is no difference in the pharmacokinetics of isotretinoin between patients with nodular acne and healthy subjects with normal skin. Vitamin A is available to humans in 2 ways: preformed vitamin A and carotenoids. Carotenoids, like beta-carotene , are found in plant foods and have to be converted by the body into vitamin A. ( 2 ) Preformed vitamin A is found in animal food sources like liver, meat , fish , and dairy. WebMD provides information about which foods to avoid while taking Isotretinoin Oral. Isotretinoin is highly lipophilic and is best absorbed when taken with food. 115,120,121 Patients should be instructed to take isotretinoin with meals. One formulation, isotretinoin with lidose, uses lipid agents to encase the medication, bypassing the need for food, and can be taken on an empty stomach. 121 Twenty healthy male subjects received 80 mg (2 X 40 mg SEG capsules) oral isotretinoin separated by two-week washout periods in an open randomized crossover design. Introduction. Vitamin A is the name of a group of fat-soluble retinoids, including retinol, retinal, and retinyl esters. Vitamin A is involved in immune function, vision, reproduction, and cellular communication [1,4,5]. Since vitamin A is fat-soluble, it is more efficiently absorbed into the bloodstream when eaten with fat. Most animal-sourced foods that are rich in vitamin A are also high in fat, but the same.