By Kelly Bonyata, IBCLC. There are several prescription drugs that have been used to increase milk supply: Metoclopramide (Reglan), Domperidone (Motilium), and sulpiride (Eglonyl, Dolmatil, Sulpitil, Sulparex, Equemote). Domperidone, Getting Started. Introduction: Domperidone (Motilium™) is a drug that has, as a side effect, the increase of milk production, probably by increasing prolactin production by the pituitary gland. Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D 2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue. Consumer information about the medication DOMPERIDONE - ORAL , includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug DOMPERIDONE - ORAL. As a paediatrician who deals now only with mothers and babies who are having difficulty with breastfeeding, I am very concerned about the warning about domperidone which was issued by the Federal Drug Administration in the US on June 7, 2004. Domperidone is not currently a legally marketed human drug and it is not approved for sale in the U.S. On June 7, 2004, FDA issued a public warning that distributing any domperidone-containing. Official Statements From Prominent Physicians. Jack Newman, MD, FRCPC As a paediatrician who deals now only with mothers and babies who are having difficulty with breastfeeding, I am very concerned about the warning about domperidone which was issued by the Federal Drug Administration in the US on June 7, 2004. Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Is domperidone really a magic breastfeeding pill? Domperidone is one of the most widely prescribed medications for new moms. For many, it’s a miracle drug for boosting milk supply, but for some women, it could be dangerous. June 7, 2004. In response to reports that women may be using an unapproved drug, domperidone, to increase milk production (lactation), the Food and Drug Administration (FDA) is warning.