The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Background: Pain is common in multiple sclerosis (MS). Duloxetine has a potential therapeutic role in treating MS-related pain. Methods: Thirty-eight MS patients were randomized 1:1 to receive duloxetine (n = 18) or matched placebo (n = 20). First thing to note, Unfortunately smoking does affects the amount of duloxetine in your system and blood stream meaning that you will loose between 40 - 50% of the duloxetine dose you take. This study is designed to primarily assess the efficacy and safety of duloxetine 60-120 mg once daily (QD) compared with placebo on the reduction of pain severity in participants with central neuropathic pain due to Multiple Sclerosis. Many multiple sclerosis researchers are actively researching causes of pain in multiple sclerosis and how best to treat and manage the pain. Read more in Multiple Sclerosis News Today. Duloxetine hydrochloride is used in MS to treat mental depression and neuropathic pain. It belongs to a group of medications known as selective serotonin and norepinephrine reuptake inhibitors (SSNRI). Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. While neuropathic pain is common in patients with multiple sclerosis (MS), pharmacological treatment can be challenging due to underlying pathophysiologic mechanisms. A new study in Pain Practice. hi, i was taking duloxetine for pain relief a few months back. i had neuropathic pain and at the time i found that it did take the edge off the pain. Background: Pain is common in multiple sclerosis (MS). Duloxetine has a potential therapeutic role in Duloxetine has a potential therapeutic role in treating MS-related pain.