What are drug interactions? Anytime you take more than one medication, or even mix it with certain foods, beverages, or over-the-counter medicines, you are at risk of a drug interaction. Drug interactions are reported among people who take Ibuprofen and Zoloft together. This study is created by eHealthMe based on reports of 2,803 people who take Ibuprofen and Zoloft from FDA, and is updated regularly. Summary. Drug interactions are reported among people who take Advil and Zoloft together. This study is created by eHealthMe based on reports of 673 people who take Advil and Zoloft from FDA, and is updated regularly. Drug interaction: zoloft vs ibuprofen (self.AskDoctorSmeeee) submitted 4 years ago by drovepasta I've been taking Zoloft for years, on and off, mostly on the last two. Zoloft (sertraline) is used to treat depression, obsessive-compulsive disorder and panic and anxiety disorders. Includes Zoloft side effects, interactions and indications. WebMD provides information about common drug or vitamin interactions for Advil PM Oral. Naproxen and Zoloft Drug Interactions – exists between naproxen and Zoloft. View detailed information regarding this drug interaction. Aleve PM and Zoloft Drug Interactions – exists between Aleve PM and Zoloft. How to use Advil Tablet. If you are taking the over-the-counter product, read all directions on the product package before taking this medication. Drug interactions that cause important changes in the action of a drug are of greatest concern. Drug interactions are complex and chiefly unpredictable. A known interaction may not occur in every individual. Learn about drug interactions between ibuprofen oral and sertraline oral and use the RxList drug interaction checker to check drug combinations.