Chronic digoxin toxicity is diagnosed probabilistically on the basis of the serum digoxin level, the renal function and clinical features, as shown below: Clinical features Probability of digoxin toxicity based on serum digoxin level In patients with atrial fibrillation (AF) and heart failure (HF) with or without systolic dysfunction, either rhythm control or rate control is an acceptable primary therapeutic option. Digitalis has been used for over 200 years to treat patients with heart failure (HF). Evidence from clinical trials supports the use of digoxin (the most widely used formulation of digitalis) to improve symptoms and reduce hospitalization in patients with HF with reduced left ventricular ejection Digoxin may enhance accessory pathway conduction in conditions such as the Wolff-Parkinson-White syndrome. Patients with Wolf-Parkinson-White syndrome that presents atrial fibrillation are at higher risk for ventricular fibrillation. Digoxin Injection official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Digoxin is used to treat heart failure, usually along with other medications. Learn about side effects, drug interactions, dosages, warnings, and more. Digoxin is a relatively safe, cheap and effective therapy for relieving recurrent symptoms in patients with congestive heart failure. It should be used as an adjunct to treatments known to reduce mortality e.g. angiotensin converting enzyme inhibitors. 532 February 20, 1997 The New England Journal of Medicine worsening heart failure and hospitalization occurred less often in patients treated with digoxin.4,5 Al- In patients with atrial fibrillation (AF) and heart failure (HF), β blockers and digoxin reduce the ventricular rate, but controversy exists concerning how these drugs affect prognosis in this setting. Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is taken by mouth or by injection into a vein.