Your Naldi Investigators. Daughter of Naldi Donna L. Hill is a native Californian and lifelong film aficionada with a particular affection for films of the silent era. Lexapro and Xanax are two common drug medications for mentally ill patients. These two drugs are significantly different medications that should be given to certain types of patients. For laymen, the difference between the two medications may not be too familiar. This article will relay the There are both similarities and differences when comparing codeine vs. oxycodone. First, the similarities. Both codeine and oxycodone are opioid pain relievers, and both have therapeutic pain-relieving benefits and are available by prescription only in the U.S. Most illegal drugs are controlled substances, but not all controlled substances are illegal, so it’s helpful to understand the distinctions between these two drug categories. Difference Between Oxycontin and Oxycodone %. Hi. I too found this site very helpful and easy to understand. I just had knee surgery, May, 8th 2013. There are many drugs of abuse out on the market that it is not uncommon for the general public to mistake methamphetamine for heroin and Percocet for Xanax. The use of opioids, including prescription painkillers and heroin, has become so pervasive that it’s called an epidemic. Two of the most prominent painkiller opiates at the center of the opioid epidemic are oxycodone and OxyContin, both of which are potent, dangerous and deadly. OxyContin (oxycodone) is a narcotic pain reliever used to treat moderate to severe pain. Includes OxyContin side effects, interactions and indications. Oxycodone is an opioid pain medication sometimes called a narcotic. Oxycodone is used to treat moderate to severe pain. The extended-release form of oxycodone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain. One of the most notable differences in morphine and heroin is the fact that one can be legally administered and the other cannot. Heroin, often sold illegally on the streets, is notably more potent than morphine, which is often prescribed for pain relieve after a severe trauma or major surgery.