Can I take Coumadin with Depakote? There is a moderate interaction between Coumadin and Depakote. You may want to consider another combination. - Page 3 Depakote is the brand name for divalproex sodium (also known as valproic acid), an anti-seizure drug used to treat epilepsy, some mood disorders (like bipolar disorder), and migraine headaches. Depakote Drug Interactions: What to Avoid Drug interaction When a substance affects the effectiveness of another drug due to their combined use, it is known as a drug interaction. Learn about Depakote side effects, dosage information, withdrawal symptoms & gene-drug interaction. How to use Depakote. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking divalproex sodium and each time you get a refill. Summary. Drug interactions are reported among people who take Depakote and Coumadin together. This study is created by eHealthMe based on reports of 486 people who take Depakote and Coumadin from FDA, and is updated regularly. Among the drugs that may potentially cause Depakote drug interactions are aspirin, diazepam, and warfarin. This eMedTV Web page explains what may happen as a result of Depakote interactions and lists other drugs that may interact with Depakote. When medicines like phenytoin or rifampin are taken together with Depakote, drug interactions may potentially occur. Among other things, these interactions may affect the level of Depakote in your blood -- which can increase your risk of developing side effects -- or decrease the effectiveness of the drug. Summary. Drug interactions are reported among people who take Warfarin sodium and Depakote together. This study is created by eHealthMe based on reports of 133 people who take Warfarin sodium and Depakote from FDA, and is updated regularly. How the interaction occurs: When warfarin is taken with valproic acid, divalproex or valproate, your body may process your warfarin more slowly.