Because polymyositis and dermatomyositis (PM/DM) are uncommon conditions, few randomized placebo controlled studies have been performed in these patients. Treatment of dermatomyositis and polymyositis As dermatomyositis and polymyositis are uncommon, there have been few randomized controlled trials, and those that have been completed enrolled small numbers of patients. Cyclosporine A versus methotrexate in the treatment of polymyositis and dermatomyositis J Vencovsky´1, K Jarosˇova´1, S Macha´cˇek1, J Study´nkova´1, J Kafkova´1, J Bartu˚nˇkova´2,DNeˇmcova´3, and F Charva´t4 We report one case of dermatomyositis and one case of polymyositis and scleroderma in which the patients' condition improved after treatment with cyclosporine (cyclosporine A). Vencovský J, Jarosová K, Machácek S, et al. Cyclosporine A versus methotrexate in the treatment of polymyositis and dermatomyositis. Scand J Rheumatol 2000; 29:95. Scand J Rheumatol 2000; 29:95. Qushmaq KA, Chalmers A, Esdaile JM. Vencovský J, Jarosová K, Machácek S, Studýnková J, Kafková J, Bartůnková J, Nemcová D, Charvát F. Cyclosporine A versus methotrexate in the treatment of polymyositis and dermatomyositis. Scand J Rheumatol. Treatment algorithm. Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer Objective: To determine the effectiveness and tolerance of treatment with cyclosporine A (CyA) or methotrexate (MTX) added to corticosteroids in patients with severe, active polymyositis (PM) and dermatomyositis (DM). Patients and methods: Thirty-six patients (20 with DM, 16 with PM) were enrolled into the study and randomized in MTX (n=17) and. Vencovský J, Jarosová K, Machácek S, Studýnková J, Kafková J, Bartůnková J, et al. Cyclosporine A versus methotrexate in the treatment of polymyositis and dermatomyositis. Scand J Rheumatol. 2000; 29 :95–102. To determine the effectiveness and tolerance of treatment with cyclosporine A (CyA) or methotrexate (MTX) added to corticosteroids in patients with severe, active polymyositis (PM) and.