Avoid using cox-2 inhibitors for pain. [No authors listed] (1) Paracetamol is the first-choice analgesic for joint pain. Nonsteroidal antiinflammatory drugs (NSAIDs), especially ibuprofen, are second-line options. Cox-2 inhibitors are no more effective than traditional NSAIDs and have no tangible advantages in terms of gastrointestinal tolerability. In contrast, they expose patients to an. Cyclooxygenase (COX). showed that selective COX-2 inhibitors are associated with a moderately increased risk of vascular events, mainly due to a twofold increased risk of myocardial infarction, and also that high-dose regimens of some traditional NSAIDs (such as diclofenac and ibuprofen. Medical uses. Some COX-2 inhibitors are used in a single dose to treat pain after surgery. Etoricoxib appears as good as if not better than other pain medications. Celecoxib appears to be about as useful as ibuprofen. Rofecoxib en celecoxib zijn vertegenwoordigers van een groep nieuwe geneesmiddelen, de COX-2-selectieve NSAID's. Deze middelen zouden door hun selectieve remming van het enzym cyclo-oxygenase (COX)-2, bij patiënten met artrose en/of reumatoïde artritis minder ernstige gastro-intestinale complicaties geven. Cyclooxygenase-2 (COX-2) inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that specifically blocks COX-2 enzymes. Nonsteroidal anti-inflammatory agents (usually abbreviated to NSAIDs) are a group of medicines that relieve pain and fever and reduce inflammation. COX-2 inhibitors have a lower potential for causing gastrointestinal (GI) bleeding compared with NS-NSAIDs [ 1, 2], but may have a higher potential for causing acute myocardial infarction (AMI) compared with naproxen [ 2–4]. Ibuprofen is an anti-inflammatory and fever-reducing medication. It can be used to treat pain and inflammation associated with many conditions such as menstrual cramps, headaches, arthritis, muscle pain,and toothaches. Use the PharmacoPhoto video 'flash-card' series to reinforce your knowledge of drug classes and specific medications. Cox-2 Inhibitors (Cox-2 inhibitor drugs) are prescription drugs used to treat the pain of arthritis conditions, menstrual cramps, and acute injuries such as sport injuries. Common side effects of COX-2 inhibitors are sinusitis, headache, flatulence, and insomnia. COX-2 vs. NSAIDs, drug interactions, and dosing information are provided. The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors (coxibs).