Both Concerta and Vyvanse are psychostimulants that are approved to treat ADHD, but there are differences. The most notable difference is that Vyvanse is a prodrug. An interesting difference between Concerta and Focalin XR is that the time release is not effective the same way. If the capsule is opened with Concerta, it is not effective, while Focalin XR can be opened and sprinkled on food for children averse to swallowing pills. Vyvanse vs Concerta. ADHD, or attention deficit hyperactivity disorder, affects a lot of children worldwide. It is a behavioral problem among a percentage of children in which the following can be found and are manifested: deficits in attention, impulsivity or acting before thinking, and lastly, hyperactivity or described as children who always. WARNING. DRUG DEPENDENCE. CONCERTA® should be given cautiously to patients with a history of drug dependence or alcoholism. Chronic abusive use can lead to marked tolerance and psychological dependence with varying degrees of abnormal behavior. Short answer. Concerta contains methylphenidate whereas Adderall contains a mixture of amphetamine salts (MAS). Although Concerta and Adderall contain different ingredients, they are both classified as CNS stimulants and are thought to work in a similar way in ADHD - by increasing the concentration of two neurotransmitters (dopamine and. Just a few years ago, ADHD med Concerta (methylphenidate ER) received the okay from the FDA for a generic version, making the less expensive methylphenidate ER available as an alternative. Concerta and Ritalin are stimulants used to treat ADHD. They have similar effects but also differences in strength, dosing, and how long you take them. Methylphenidate ER (Concerta) is an expensive drug used to treat attention-deficit hyperactivity disorder. It is also used to treat narcolepsy. WARNING: DRUG DEPENDENCE. Concerta ® should be given cautiously to patients with a history of drug dependence or alcoholism. Chronic abusive use can lead to marked tolerance and psychological dependence with varying degrees of abnormal behavior. Concerta (methylphenidate extended release tablets) is a central nervous system stimulant used for treating attention deficit hyperactivity disorder. Side effects of Concerta include.