The maximum dose is 4 g (4000 mg); this would be equivalent to 8 extra strength tablets. Although long term use at this dose is common in the UK, it can cause serious liver damage over decades of use. Ibuprofen is an medicine used to manage mild to moderate pain, fever, inflammation, menstrual cramps, and types of arthritis. Common side effects are drowsiness, nausea, diarrhea, constipation, and ringing in the ears. Ibuprofen is an NSAID, which can cause stomach ulcers in some people. It also interacts with many other drugs. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Krauser on can you take aleve and aspirin together: Neither metaphors nor nsaids should be mixed. Mixing results in double the toxicity but no significant benefit (if full doses of one are used alone). These medications work together to provide an optimal level of care. NSAIDs and analgesics are two of the most common forms of medication prescribed, and they each effectively target symptom relief in different ways. Many drugs might interact with creatine and increase the risk of kidney damage. Possible drug interactions include: Nephrotoxic drugs. Because taking high doses of creatine might harm your kidneys, there is concern about combining creatine with drugs that might damage the kidneys (nephrotoxic drugs). What Are the Suggested Alternatives? Although Dr. Danica Baron, MD, an assistant medical director at ParaDocs Worldwide Inc., advises against combining ibuprofen and aspirin, she said it's safe to. The recommended dose of ibuprofen depends on a person’s age. For adults. The recommended dosage for adults is one or two 200 milligram (mg) tablets every four to six hours. Nasal decongestants help unclog a congested nose. They work by narrowing the blood vessels in the lining of your nose so that the swollen tissue shrinks and decreases mucous production. Doctors give unbiased, trusted information on whether Advil can cause or treat Knee Pain: Dr. Ellis on aleve vs advil for knee pain: The same. One may work better than the other but make sure you take it with food so that it doesn't upset your stomach Drinking alcohol while taking medication may seem like no big deal, but combining the two can often be very dangerous. If you’ve been prescribed medication and aren’t sure if it’s OK to.