First of all, Clomid’s use forces your body to ovulate. It affects estrogen level. Because of its impact on estrogen level, it can cause your uterine line to be thin. Clomid can severely affect the quality and amount of your cervical mucus. When cervical mucus is exposed to estrogen, the fact that it is watery and thin helps the sperm travel up to the fallopian tubes easily. However, when. Clomid Side Effects and Risks. Clomid works by tricking the body into thinking there isn't enough circulating estrogen. To do this, it blocks the receptors in the body that react to the estrogen hormone. Most side effects of Clomid are caused by these perceived low estrogen levels. Clomid or Serophene. Clomiphene citrate has been used for more than 40 years. Your. Among women who do start to ovulate, as many as 50% are able to get pregnant. Side effects: Most are mild and. You won't ovulate on the five days you're taking Clomid pills. However, with your first dose, Clomid begins a chain reaction that will eventually lead to ovulation. In short, the hormone FSH (follicle-stimulating hormone) signals the ovaries to grow and mature eggs (encased in follicles of fluid) to be released via ovulation. As the follicles on the ovaries grow, they release estrogen. The. Any number of conditions can hamper the body's ability to ovulate effectively. One of the primary ways to address this challenge is with medications that stimulate the ovarian follicles to produce multiple eggs in one cycle. The two most common fertility medications used to promote ovulation include Clomiphene Citrate (Clomid or Serophene) and Gonadotropins (Follistim, Menopur, Bravelle and. Most patients ovulate following the first course of therapy. However, if the patient fails to ovulate, a second course of 100 mg/day for 5 days may be given as early as 30 days following the initial course. A third course of 100 mg/day for 5 days may be given after 30 days, if necessary.