Aspirin and Tylenol may be taken together. However, according to Drugs.com, it is vital to not exceed the recommended dosage for either of these medications. However, longterm mixing of acetaminophen (the ingredient in Tylenol) and aspirin can result in renal (kidney) damage. It will not happen if you mix them once or twice, but mixing repeatedly over a long period of time is dangerous. Acetaminophen and aspirin is a combination medicine used to treat minor arthritis pain, back pain, and muscle aches. Acetaminophen and aspirin may also be used for purposes not listed in this medication guide. Can you take aspirin and ibuprofen together to treat or prevent different conditions? Learn about these two drugs and how to take each safely. Learn about these two drugs and how to take each safely. Can I take aspirin and Tylenol (acetaminophen) together? Is it ok to take tylenol (acetaminophen) and aspirin together for a headache? It's been three hours since I took one 500mg pill of Tylenol, (acetaminophen) would it be safe to take two pills of 325mg Bayer aspirin? Celebrex and Tylenol are in different classes of pain medication, and when you take them both together, they work much better than either one alone. Can patients mix Tylenol and NyQuil together Patients should never take Tylenol and Nyquil together! Both products contain acetaminophen as an active ingredient, so if they mix them, they may exceed the allowable daily dose (more than 4g), causing potentially fatal condition called Acetaminophen’s induced hepatic necrosis. Can I take Tylenol and a daily aspirin at the same time? It has been observed that Aspirin and Acetaminophen (Tylenol) both are widely used analgesic and antipyretic drugs to treat fever, headaches, and other minor aches and pains. Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.