Hello nickki. I did some reading up on your question and found out that, and this holds true for most antibiotics and alcohol, that the doxycycline, leaves your body much faster. Doxycycline is listed as causing a minor interaction when taken with alcohol, according to Drugs, so drinking is not recommended while taking this medication. Even if a doctor hasn’t been consulted, a patient who is taking doxycycline could possibly drink small amounts, approximately equal to one or two glasses of wine or cans of beer per day with minimal negative effects, if that alcohol is generally consumed very slowly. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Ein on can you drink alcohol while taking doxycycline hyclate: Alcohol and Doxycycline are fine together but drink in moderation as alcohol can interfere with your ability to fight an infection. However, since it can potentially affect the liver, and alcohol is already hard on the liver, it is probably a good idea not to drink while taking it. share with friends Share to: A couple of glass of alcohol won't hurt, while you are taking doxycycline. Just separate the dose from when you drink alcohol, to ensure that the antibiotic is absorbed properly. Thorough, personalized responses from Doctors: Dr. Killian remarks on whether you should drink alcohol while taking Doxycycline. Can I consume alcohol while taking Doxycycline Hyclate 100mg for 21 days? I do not see any restrictions on the bottle. Thanks. Alcohol and Doxycycline. While alcohol is not prohibited while being treated with doxycycline it is also no recommended. While one to two drinks will not cause adverse effects, if you binge drink or are a chronic alcohol drinker the effectiveness of the medication can be lessened. Drinking alcohol while on Lithium IS NOT OK! Lithium can cause dehydration and IT'S IMPORTANT that you drink at least 8 - 8 ounce glasses of water per day!!!!!.