I took a small amount of Mucinex for cough, 1 allegra for allergy, and now i would like to take two tylenol (acet more I took a small amount of Mucinex for cough, 1 allegra for allergy, and now i would like to take two tylenol (acetaminophen) for back pain. My husband and I do use these products together, but I would suggest you check with your local pharmacist , depending on the use of other prescribed meds you may take or conditions you may have. While Mucinex does work for the mobilization of mucous I believe the company is trying to expand it's customer base by adding the DM (GUAIFENESIN / DEXTROMETHORPHAN) which is of all things a potential cough suppressant. There are no drug interactions between Mucinex DM and Tylenol. They are safe to take together. It’s always a good idea to look into potential drug interactions when combination products are involved. Can I Take Tylenol With Mucinex? I am currently taking the medication Effexor, and was wondering if it was okay to take Tylenol and Mucinex together Mucinex (guaifenesin) can safely be taken with Robitussin (dextromethorphan) and there is no interaction between the two medications. However, Robitussin is a brand name that is used for a variety of products, all of which contain different ingredients. Can I take Tylenol with Mucinex?. Can I take Zzzquil and Mucinex together? Can Mucinex and Robitussin be taken simultaneously? Can you take Mucinex, Loratadine, and ibuprofen together? When should I take mucinex? What other medicines can I take with Mucinex DM? Can I take Nyquil and Tylenol together? Can I take Benadryl if I've already taken Tylenol? Can you take Meloxicam with Tylenol? Can. Can I take Advil cold and sinus with Mucinex D together? Advil Cold and Sinus is a combination of two active ingredients Ibuprofen + Pseudoephedrine while Mucinex D except guaifenesin also contains pseudoephedrine as active ingredients. Tylenol (acetaminophen) is very good at combatting a soar throat. And this isn't a problem to take together. Which mucinex are you taking? I like the green one with both guaifenesin and dextromethorphan. Take Tylenol Sinus as directed, and, rather than taking the next dose, switch to Mucinex for that round and repeat. By following this routine, you will gain the benefits of both medications without increasing your risk of overdose.