My doctor wants me to try taking both Elavil and Topomax together at night before bed. The Topomax should conteract the weight gain issues of the Elavil, but I just can't get past those horrible side effects, I feel like I am floating on a cloud, real woosy and very tired the next day. I was diagnosed with epilepsy (no known cause) in June 2010 and take 200 mg of Lamictal XR and 200 mg of topiramate a day to control it. My seizures (tonic clonic) are under control. You can take these 2 drugs together but there are some long termand short term effects that may come up. Some of these thingsinclude irregular heart rate, depression, and anxiety. This medicine can take 4 to 6 weeks for the full effects of this medication to kick in, especially for people taking it for migraines. Children taking Topamax (topiramate) for long periods of time need to have their dose adjusted by their pediatrician as they grow. Learn about drug interactions between amitriptyline oral and topiramate oral and use the RxList drug interaction checker to check drug combinations. Ask your doctor before using amitriptyline together with alcohol, this can alter the effects of. View more Ask your doctor before using alcohol together with topiramate. Hi, I am Neuro Doctor, an American Board Certified Neurologist with vast clinical experience. Topamax and Amitriptyline can be used together and there are no serious or major interactions between these 2 meds. Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. Hey everyone, I went to the GP yesterday because my amitriptyline has stopped working, so he prescribed me topiramate. He didn't know I was on 50mg amitriptyline and would have to taper off it, but when I told him he said it wouldn't be a problem and I could take the 2 together without any problems whatsoever. has anyone tried Amitriptyline and it worked? how long does it take to work and at what dosage? I am just concerned that the anxiety is being caused by Amit. and I don't want to keep taking it if it does not work.