Depakote. Depakote Formulations. JAMA Psychiatry. Chronic Divalproex Sodium to Attenuate Agitation and Clinical Progression of Alzheimer Disease. Mental Health Clinician. 2012;1(11):14. Dosing of Valproate in an Elderly Population With Dementia: Evaluation of Discontinuations and Dose Reductions. In a clinical trial of DEPAKOTE as monotherapy in patients with epilepsy, 34/126 patients (27%) receiving approximately 50 mg/kg/day on average, had at least one value of platelets ≤ 75 x 109/L. Approximately half of these patients had treatment discontinued, with return of platelet counts to normal. In the remaining patients, platelet counts normalized with continued treatment. In this stud.