Bupropion is used to treat depression and seasonal affective disorder, and to help people quit smoking. Learn about side effects, warnings, dosage, and more. In Summary. Commonly reported side effects of bupropion include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, and xerostomia. Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Precautions. Drug information provided by: IBM Micromedex. It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Description Bupropion is a non-tricyclic antidepressant drug. Tricyclic antidepressants, which have a three-ring chemical structure, may cause troublesome side effects, including sedation, dizziness, faintness, and weight gain. Find a comprehensive guide to possible side effects including common and rare side effects when taking Wellbutrin (Bupropion Hcl) for healthcare professionals and consumers. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mental/mood disorders, and smoking cessation. Antidepressants can help prevent suicidal thoughts. DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Often sold under the brand name Wellbutrin, bupropion is mainly used to treat depression. It can also help people to stop smoking. Some research suggests that bupropion can have additional.