My urologist prescribed me Uribel. My concern after reading the literature is if this medication should not be taken by someone allergic to sulfa drugs (I had severe welts from Bactrim DS)? My concern after reading the literature is if this medication should not be taken by someone allergic to sulfa drugs (I had severe welts from Bactrim DS)? The 7 Best Natural Muscle Relaxers Medically reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT on August 2, 2017 — Written by Summer Fanous Chamomile How to use Bactrim DS. Take this medication by mouth, as directed by your doctor, with a full glass of water (8 ounces / 240 milliliters). If stomach upset occurs, take with food or milk. Brandon what antibiotics are you taking? Cipro, Zithromax, Bactrim and Septra DS can make your urine a different color. Overall listen to your body and don't risk your health, renal failure is no fun. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with metaxalone, including prescription and over-the-counter medicines, vitamins , and herbal products. Is Bactrim a Muscle Relaxants? Can I take Bactrim with Muscle Relaxants? 283 patient discussions about Bactrim and Muscle Relaxants. Note: This document contains side effect information about sulfamethoxazole / trimethoprim. Some of the dosage forms listed on this page may not apply to the brand name Bactrim. Muscle relaxants are used to treat two different conditions: (1) spasticity from upper motor neuron syndromes as occurs in multiple sclerosis and (2) muscular pain or spasms from peripheral musculoskeletal diseases or injury such as low back pain. I'm on meds for uti and bronchitis, was prescribed muscle relaxers last night for severe back pain. They didn't say anything about not taking them together. Muscle relaxants treat two main conditions: spasticity (stiff, rigid muscles) caused by conditions such as cerebral palsy, multiple sclerosis, and stroke; or muscle spasms which are typically temporary and associated with conditions such as tension headache, low back pain, or fibromyalgia.