Baclofen (Lioresal, Kemstro) is a muscle relaxant drug used for treating muscle spasms, rigidity, and pain from conditions such as multiple sclerosis (MS). Common side effects of baclofen are low blood pressure, vomiting, nausea, headache, and seizures. Several drugs interact with baclofen. Baclofen (β-parachlorophenyl GABA) is een spierverslapper. Het is een gamma-aminoboterzuur-agonist (GABA-B-agonist) die in het bijzonder bij oromandibulaire dystonie wordt voorgeschreven. Baclofen comes as a tablet to take by mouth. It usually is taken three times a day at evenly spaced intervals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Baclofen oral tablet is only available as a generic drug. Baclofen only comes as a tablet you take by mouth. Baclofen is used to treat muscle spasms. Don’t stop taking this drug without talking. INDICATIONS. Baclofen tablets are useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Find patient medical information for Baclofen Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Wirkung. Baclofen wirkt als spezifischer Agonist an den GABA B-Rezeptoren der Synapsen und Nerven des Rückenmarks von Säugetieren. Ohne entsprechende ständige Kontrolle aus dem Gehirn überwiegen im Rückenmark die spastischen Reflexmechanismen. Baclofen is a muscle relaxer used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. Includes baclofen side effects, interactions and indications. Avoid abrupt discontinuation of intrathecal baclofen therapy. Abrupt discontinuation of intrathecal baclofen, regardless of cause, has resulted in severe reactions including high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multi-system organ failure, and. Baclofen official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.