Traditionally been considered the DOC for the treatment of a dental abscess. Antibiotic therapy alone, without surgical drainage, may not be effective because of poor antibiotic penetration into the abscess cavity, ineffectiveness at low pH levels, and the inoculum effect. A skin abscess is a localized collection of pus that generally develops in response to infection or to the presence of other foreign materials under the skin. I have a severe abscess tooth on the lower left side of my mouth. I have been to the ER and the dentist. I'm on antibiotics (clindamycin) 600mg ibuprofen and hydrocodone for pain. A tooth abscess is an infection of the tooth that is usually caused by untreated tooth decay or gum disease, or a serious tooth injury that affects the pulp, such as fracture. Given metronidazole for a big dental abscess in Jan. It worked well. No nasty side effects. Week later the 'bad' tooth broke off , exposing the roots. 500 mg PO on first day of therapy, followed by 250 mg PO once daily on days 2 to 5. Guidelines recommend azithromycin as a monotherapy option in previously healthy outpatients with no risk factors for drug-resistant S. pneumoniae and without therapy in the preceding 3 months. Dear TxGramma, Yes, Azithromycin is used for dental infections and abscesses, among other things. If you're talking about using some old leftover med you have though, use caution. Periodontal Abscess. The ideal situation with an abscess is to achieve some form of drainage, and with periodontal abscesses, often this can be achieved by RSD in the pockets surrounding the abscess. If you are dealing with a dental abscess or tooth infection, antibiotics are the medication to calm down the pain and fight bacteria. The most common and best antibiotics for tooth infection are: amoxicillin, clindamycin and metronidazole. Tooth abscess can turn into a serious threat to your health. If you are looking for natural, antibiotic-free solutions for treatment, read through for the 19 best abscess tooth home remedies!.