Advil vs Tylenol comparison. Advil and Tylenol are both medications used to relieve pain and reduce fevers. Advil also has anti-inflammatory properties, so it is used for treating arthritis or joint pain. There are differences in the mechanisms of action and side effects of the two dr. Recent medical research has shown that non-steroidal anti-inflammatories (NSAIDs) like Advil, Motrin, Aleve, ibuprofen, aspirin, naproxen, etc. may be harmful to runners' kidney function if taken within 24 hours of running; only acetaminophen (Tylenol) has been shown to be safe. Some important information about mixing two of the most commonly used over-the-counter medications—Tylenol (acetaminophen) and aspirin. Advil PM dosing instructions, ingredients, safety and drug facts. Get the trusted pain relieving power of Advil with a gentle, non habit forming sleep aid. We see ads daily promoting the pain relieving properties of Motrin, Aleve, Tylenol, Bufferin, and similar over-the-counter (OTC) products found on drugstore shelves. Advil and Aleve are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and reduce fever. Though they are different drugs, they fall within the same drug class. Not all of these common drugs have the same effect and each one is assigned for a different kind of pain. Like superheroes, each pain reliever has its own set of strengths and weaknesses. The main differences between Advil, Tylenol, Aleve, and Aspirin summed up in one chart Which drug is safer and better for different kinds of pain? Advil and Aleve are popular over-the-counter painkillers that have more similarities than differences between them.